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KMID : 1103720110650060595
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Journal of the Korean Society of Radiology
2011 Volume.65 No. 6 p.595 ~ p.601
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Clinical Significance and Pathologic Outcomes of Coarse Heterogeneous Calcifications Detected on a Mammography
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Lim Hyun-Ju
Cho Kyu-Ran
Seo Bo-Kyoung
Woo Ok-Hee
Whang Kyu-Won
Oh Yu-Whan
Bae Jung-Won
Park Kyung-Hwa
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Abstract
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Purpose: To investigate the clinical significance and pathologic outcome of coarse heterogeneous calcifications (CHCs) detected on a mammography.
Materials and Methods : A retrospective review of our institutional mammographic database revealed 65 women with CHCs. Of these, we included 27 with pathologic verification (n = 27; benign in 13, malignancy in 14). Mammograms were interpreted in terms of CHC distribution (clustered, linear, segmental, regional, or diffuse), the area of CHCs, and associated findings. We also evaluated the presence of mass, ductal change, or change of parenchymal echogenicity on ultrasound images (n = 26). We correlated and statistically analyzed the radiologic features with pathologic findings.
Results: The individual distributional descriptors of CHCs predicted the risk of malignancy as follows: clustered (8/22); linear (1/2); regional (0/1); segmental (5/5). The segmental distribution predicted malignancy (p < 0.05). The CHC area in malignant lesions was larger than that of benign lesions (p < 0.05). Mammography revealed an associated mass in 2 out of 13 benign and 5 out of 14 malignancies. However, an increased risk of malignancy was not shown by the presence of an associated mass and its larger size. Ultrasound findings were not significant for predicting malignancy.
Conclusion: CHCs were verified as malignancy in 52% of cases, especially when characterized by segmental distribution and larger CHC areas on mammography.
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KEYWORD
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Coarse Calcification, Mammography, Breast, Breast Cancer, Diagnosis
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